Principal Scientist in Oxford

Job description

Senior - Principal Scientist

A pioneering biotech company at the forefront of cancer immunotherapy is seeking a Senior or Principal Scientist to join their dynamic team. This organization is focused on developing next-generation T-cell receptor (TCR)-based therapies to address solid tumors—areas historically difficult to treat with conventional immunotherapies.

Role Summary

The successful candidate will play a key role in driving the engineering, in vitro, and in vivo validation of TCR-based engagers. This includes hands-on work in molecular biology, protein science, and cell-based assays, as well as collaboration across multidisciplinary teams to advance therapeutic candidates toward clinical development.

Key Responsibilities

• Lead in vitro and in vivo validation of TCR-based T cell engagers.
• Design and characterize TCRs targeting proprietary and partnered disease indications.
• Execute protein science workflows, including expression, purification, and biophysical analyses of recombinant TCRs.
• Perform molecular biology tasks: cloning, mutagenesis, DNA isolation, and library prep for sequencing.
• Manage cell culture work, including media preparation, cell line maintenance, and cryopreservation.
• Contribute to the creation, revision, and maintenance of laboratory protocols and standard operating procedures (SOPs).

Required Qualifications

• PhD in Immunology, Cell Biology, Biochemistry, or related discipline, with:
• 2-3 years of industry experience.
• Demonstrated experience with in vitro and in vivo validation of T cell engagers, ideally through to IND-enabling studies.
• Solid understanding of molecular biology techniques (e.g., cloning, PCR).
• Hands-on experience with protein expression, purification, and biophysical characterization.
• Experience with cell-based assays (e.g., flow cytometry, ELISA) is desirable.
• Familiarity with NGS library preparation and data analysis pipelines (e.g., using R) is a plus.
• Prior SOP development and documentation experience is advantageous.

Extra information

Status

Open

Education Level

Secondary School

Location

Oxford

Type of Contract

Part-time jobs

Published at

09-07-2025

Full UK/EU driving license preferred

No

Car Preferred

No

Must be eligible to work in the EU

No

Cover Letter Required

No

Languages

English