Head of Pipeline Biology in Oxfordshire

Job description

We are seeking an innovative and hands-on scientific leader to serve as Head of Pipeline Biology, responsible for advancing the biological development of our client's pioneering bispecific TCR therapeutics targeting AML and solid tumours. This is a critical leadership role in progressing first-in-class, first-in-human molecules to the clinic.

Key Responsibilities

Scientific Leadership & Strategy

• Lead the preclinical biology group, overseeing in vitro and in vivo testing of bispecific TCR molecules.
• Design and implement assays to assess binding specificity, T cell activation, and T cell-mediated killing.
• Develop testing strategies to evaluate efficacy, safety, and mechanism of action.
• Collaborate with Protein Engineering to optimise candidate molecules.

Regulatory & Translational Development

• Drive the generation of data packages to support regulatory submissions (MHRA, FDA, EMA).
• Contribute to Clinical Trial Authorisation (CTA) and IND/NDA applications.
• Engage with regulatory bodies and external experts to ensure alignment with global standards.

Team & Operational Leadership

• Manage and mentor a growing team of cell biologists (initially 3–4 scientists).
• Oversee budgets, timelines, and reporting for biological testing activities.
• Present findings to the Senior Leadership Team and external stakeholders.
• Foster a culture of innovation, collaboration, and scientific excellence.

Experience & Qualifications

Background

• PhD in Immunology, Cell Biology, Molecular Biology, or a closely related discipline.
• At least 5 years of R&D experience within biotechnology or pharmaceutical settings, ideally in TCR therapeutics, bispecifics, or immuno-oncology.
• Demonstrable hands-on experience in evaluating the safety and efficacy of high-affinity soluble TCR molecules.
• Proven track record in non-clinical development and regulatory interactions.
• Experience contributing to successful regulatory submissions and clinical trial initiation.

Technical Expertise

• In-depth understanding of T-cell biology, cellular assays, and molecular techniques, including target binding, T-cell activation, and cytotoxicity assays both in vitro and in vivo.
• Proficiency in lentiviral transduction, molecular cloning, and engineering of isogenic cell lines.
• Experience in maintaining diverse cell systems, including human organoids, and primary human cells.
• Skilled in multi-colour flow cytometry, EliSpot, luminometry, and fluorescence-based assays.

Leadership & Communication

• Demonstrated leadership in developing and implementing scientific strategies.
• Excellent communication and presentation skills, with the ability to convey complex scientific data to senior leadership and external audiences.
• Strong record of cross-functional collaboration and evidence-based decision-making.
• Experience managing budgets, project timelines, and preparing technical reports.
• Ability to represent an organisation’s work through publications and scientific presentations.
• Familiarity with the requirements for preparing preclinical data packages for CTA (MHRA) and NDA (FDA/EMA) submissions.

Extra information

Status

Open

Education Level

Secondary School

Location

Oxfordshire

Type of Contract

Part-time jobs

Published at

17-11-2025

Full UK/EU driving license preferred

No

Car Preferred

No

Must be eligible to work in the EU

No

Cover Letter Required

No

Languages

English